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Cathepsin B rabbit pAb
一鍵復(fù)制產(chǎn)品信息
ES1869
規(guī)格: 價格:
50μL ¥1280.00
100μL ¥1980.00

Overview 文獻(xiàn)(1)

Product name: Cathepsin B rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Cathepsin B. AA range:168-217
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 38,40,25kD
GeneID: 1508
Human Swiss-Prot No: P07858
Cellular localization: Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
Background: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.
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