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產(chǎn)品中心

Apaf-1-ALT rabbit pAb

一鍵復制產(chǎn)品信息

ES1672

規(guī)格：	價格：
50μL	￥1280.00
100μL	￥1980.00

下載說明 ①

Overview

Product name:	Apaf-1-ALT rabbit pAb
Reactivity:	Human;Rat;Mouse;
Alternative Names:	APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19; dJ179L10.2; likely ortholog of mouse monocyte macrophage 19
Source:	Rabbit
Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human APAF-1-ALT. AA range:289-338
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	27kD
GeneID:	317
Human Swiss-Prot No:	O14727-6
Cellular localization:	Cytoplasm .
Background:	This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Western Blot analysis of various cells using Apaf-1-ALT Polyclonal Antibody diluted at 1:500
Western Blot analysis of COLO205 cells using Apaf-1-ALT Polyclonal Antibody diluted at 1:500
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using APAF-1-ALT Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COLO205 cells, using APAF-1-ALT Antibody. The lane on the right is blocked with the synthesized peptide.

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