久草精品视频在线播放,中文人妻AV久久人妻水密桃,av免费观看精品,亚洲五月激情综合图片区日本成熟少妇A∨网站,久久看亚洲欧美,久久久久久人妻精品一区,久久亚洲Aⅴ无码影院

<ins id="f9ykn"></ins>

<ins id="f9ykn"></ins>

產(chǎn)品中心

Shb (phospho Tyr246) rabbit pAb

一鍵復(fù)制產(chǎn)品信息

ES1402

規(guī)格：	價格：
50μL	￥1280.00
100μL	￥1980.00

下載說明 ①

Overview

Product name:	Shb (phospho Tyr246) rabbit pAb
Reactivity:	Human;Mouse
Alternative Names:	SHB; SH2 domain-containing adapter protein B
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	Synthesized phospho-peptide around the phosphorylation site of human Shb (phospho Tyr246)
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	55kD
GeneID:	6461
Human Swiss-Prot No:	Q15464
Cellular localization:	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Associates with membrane lipid rafts upon TCR stimulation.
Background:	domain:The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.,function:Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.,PTM:Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGRF1 or VEGFR2 activation.,similarity:Contains 1 SH2 domain.,subcellular location:Associates with membrane lipid rafts upon TCR stimulation.,subunit:Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2.,tissue specificity:Widely expressed.,

Western Blot analysis of various cells using Phospho-Shb (Y246) Polyclonal Antibody
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Shb (Phospho-Tyr246) Antibody
Western blot analysis of lysate from 293 cells, using phospho-Serhb (Phospho-Tyr246) antibody.
Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

關(guān)閉

在線咨詢

Online consultation

在線咨詢
技術(shù)支持

關(guān)注微信公眾號

微信掃一掃立即咨詢

微信電腦端咨詢

微信掃一掃立即咨詢

微信電腦端咨詢

關(guān)閉