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Cleaved-Caspase-9 p35 (D315) rabbit pAb
一鍵復(fù)制產(chǎn)品信息
ES1009
規(guī)格： 價格：
50μL ￥1280.00
100μL ￥1980.00

Overview

Product name: Cleaved-Caspase-9 p35 (D315) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6
Source: Rabbit
Dilutions: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 9. AA range:266-315
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 35 46kD
GeneID: 842
Human Swiss-Prot No: P55211
Cellular localization: nucleus,mitochondrion,cytosol,apoptosome,
Background: CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
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